Stanford Abdominal Transplantation

2018: Stanford Abdominal Transplant Breaks All Records!!!

***The Pediatric Transplant Program at Stanford Children’s is the number one program in volume in the nation again for 2017.  This was a milestone year for the programs. 


***The Kidney transplant program worked non-stop doing 55 transplants for an all-time high and doubling their volume.


***Heart transplant did it’s 400th heart transplant which included a technically challenging combined heart-liver transplant highlighting the strong collaboration and partnership across the organ programs.


***January 6th marked the 50th anniversary of the first adult heart transplant done by Dr. Shumway here at Stanford.


***Liver transplant launched a Regional Liver Tumor Program including a monthly multi-disciplinary teleconference to remotely facilitate discussion with physicians across the country to collaborate on the most complicated and highest risk liver tumor cases.

 

No other team has this level of expertise combining so many different specialties all working together!!!

 

Announcements

Abdominal Transplantation Receives $3.6M Grant For Pediatric Transplant Research

The National Institutes of Health has awarded Stanford's Division of Abdominal Transplantation two U01 grants to perform innovative studies on samples from pediatric transplant recipients. The total awarded for these grants is more than $1,200,000 each year for the next three years. The studies receiving funding are:

· Exosomes and the Immune Response in Allograft Outcomes in Pediatric Transplant Recipients (Krams, Martinez, Esquivel, Boyd, Bendall, Bernstein, Weinberg, Trickey); and

· The Impact of Epstein-Barr Virus Infection on the Immune Response in Pediatric Transplant Recipients (Martinez, Krams, Esquivel, Boyd, Bendall, Davis, Weinberg, Bernstein, Trickey).

Both studies utilize patient samples from more than 900 children who are enrolled in the on-going Stanford clinical trial: CTOT-C06, Biomarkers for Post-Transplant Lymphoproliferative Disorders in Children.

Dr. Olivia Martinez’s research will focus on Epstein-Barr virus (EBV) and how the infection shapes the post-transplant immune response in pediatric transplant recipients.

“EBV is associated with serious complications in children who receive organ transplants,” said Martinez. “The study will use high dimensional, cutting-edge approaches with the goal of identifying unique immune-based signatures that promote functional EBV immunity and long-term graft survival.”

The study led by Dr. Sheri Krams will examine the innate and alloimmune responses after transplant.

“Specifically, the role of exosomes and the miRNome will be analyzed to establish markers associated with acute rejection and stable graft function,” said Krams. “These new awards will allow us develop novel immune-mediated biomarkers that are associated with, and predictive of, graft outcomes and protection from viral infection, and thus bring a personalized approach to the medical management of children that receive organ transplants.” 

A 6-month-old baby shouldn’t be fighting for his life. He shouldn’t have to be hurriedly baptized in a hospital room in advance of an emergency liver transplant. His young parents shouldn’t be stricken by grief and guilt during what should be a glorious period in their lives.

But this is where the Hernandez family finds itself. They currently are keeping vigil more than 100 miles away from their home in Sacramento, at the Lucile Packard Children’s Hospital Stanford in Palo Alto, praying for their son to survive an extremely rare disease that can be fatal unless luck and fate intervene. [...]


Third International Workshop on Clinical Tolerance

Stephan Busque, Samuel Strober, John Scandling at the Third International Workshop on Clinical Tolerance-Sept. 8-9, 2017 sponsored by The Stanford Institute for Immunity, Transplantation and Infection.


'Liverversary': Eugene girl celebrates her liver transplant one year later

10-year-old Lily Richard of Eugene wouldn’t be alive today if it wasn’t for a liver transplant she got exactly one year ago Sunday.  Lily’s family celebrated what they called her "Liverversary" on August 6, a one-year celebration of Lily’s new liver.  What they thought was a case of the stomach flu ended up being liver failure.  Lily was immediately flown to Stanford in California to await a liver transplant.  After being put on the top of the wait list, Lily received her transplant two days later.  Now her family is celebrating Lily’s new liver and bringing awareness about organ donations to the community.


Dr. Marc L. Melcher was featured in ASTS new briefs:
Numerous kidney exchange (kidney paired donation [KPD]) registries in the United States have gradually shifted to high-frequency match-runs, raising the question of whether this harms the number of transplants. We conducted simulations using clinical data from 2 KPD registries—the Alliance for Paired Donation, which runs multihospital exchanges, and Methodist San Antonio, which runs single-center exchanges—to study how the frequency of match-runs impacts the number of transplants and the average waiting times.


Congratulations to Trinidad Cisneros on his successful Immunology Thesis Defense

“Role of NK cells and the NK cell receptor NKG2D in the recognition and killing of stem cell derived hepatocyte-like cells”


Surgery Resident Finalist in Competition

Adam Sang, M.D. is a Stanford Surgery resident doing research in the Transplant Labs.  He is the Ernest and Amelia Gallo Endowed Postdoctoral Fellow.   He was selected as a finalist for the 2017 Northern California Chapter of the American College of Surgeons Surgical Trainee Research Competition.

Robbie Turner was only 28 years old when she was diagnosed with polycystic kidney disease — a genetic disorder that causes clumps of cysts to form in the kidneys, reducing their function over time. She knew she’d need a kidney transplant one day, and for many years, Turner and her husband thought he would be her kidney donor as he’d been approved as a perfect candidate. [...]


Dr. Busque Wins Award

The Arthur L. Bloomfield Award in Recognition of Excellence in the Teaching of Clinical Medicine.  Stephan Busque was one of the faculty that received this award.


Yarl Balachandran Wins Award

Yarl Balachandran, a Postdoc fellow in transplant immunology, was selected as a 2017 ATC Award Program winner out of approximately 100 applicants.


Marc Lucia Perez Wins Award

Marc Lucia Perez, a postdoc from the Division of Abdominal Transplantation presented an abstract entitled "STRATEGY FOR ANALYSIS OF DONOR-SPECIFIC ANTIBODY REPERTOIRE: PAIRED IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN ANALYSIS OF INDIVIDUAL MEMORY B CELLS" at ESOT 2017 in Barcelona. He received the Young Investigator Award for his presentation.


Chief's Message


The Division of Abdominal Transplantation’s mission is to provide the highest quality patient care for our patients, to foster translational research, and to train the best transplant surgeons for the future.  We are highly committed to improving the care of our transplant patients through innovative clinical and basic science research both in the hospital and the lab.

Clinically, we offer transplantation services at Stanford Hospital & Clinics (SHC) and Lucile Packard Children's' Hospital at Stanford (LPCH).  Leading P.I.’s at Stanford University School of Medicine spearhead our research efforts by recruiting top post-doc fellows as well as attracting new doctoral candidates to the program.

Transplantation is also an important branch of the Immunity, Transplantation and Infection Institute at Stanford University (ITI).  ITI fosters multidisciplinary research projects to investigate in much greater detail the function of the immune system in health and disease including transplantation.  To carry out this mission, the Human Immune Monitoring Center was created.

~Dr. Carlos O. Esquivel